去甲汉黄芩素

**去甲汉黄芩素**
臨床資料
其他名稱	5,7,8-Trihydroxyflavone; 5,7,8-THF
识别信息
	IUPAC命名法 5,7,8-trihydroxy-2-phenylchromen-4-one; ;
CAS号	4443-09-8
PubChem CID	5281674;
ChemSpider	4444993;
UNII	70U0WT21IB;
KEGG	C10113;
ChEBI	CHEBI:7642;
ChEMBL	ChEMBL485250;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID20196171 ;
化学信息
化学式	C15H10O5
摩尔质量	270.24 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C=C3O)O)O;
	InChI InChI=1S/C15H10O5/c16-9-6-11(18)14(19)15-13(9)10(17)7-12(20-15)8-4-2-1-3-5-8/h1-7,16,18-19H; Key:ZFKKRRMUPBBYRS-UHFFFAOYSA-N;

去甲汉黄芩素（英語：Norwogonin，也称为5,7,8-三羟基黄酮，5,7,8-trihydroxyflavone，缩写5,7,8-THF）是一种天然黄酮类化合物，存在于黄芩（学名：Scutellaria baicalensis）等植物中^[1]。其生物学活性接近7,8-二羟基黄酮（7,8-DHF）^[2]。

参考文献[编辑]

^ Miyasaki Y, Rabenstein JD, Rhea J, Crouch ML, Mocek UM, Kittell PE, et al. Khan AU , 编. Isolation and characterization of antimicrobial compounds in plant extracts against multidrug-resistant Acinetobacter baumannii. PLOS ONE. 2013, 8 (4): e61594. Bibcode:2013PLoSO...861594M. PMC 3632535 . PMID 23630600. doi:10.1371/journal.pone.0061594.
^ Liu X, Chan CB, Jang SW, Pradoldej S, Huang J, He K, et al. A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect. Journal of Medicinal Chemistry. December 2010, 53 (23): 8274–86. PMC 3150605 . PMID 21073191. doi:10.1021/jm101206p.

[1] Miyasaki Y, Rabenstein JD, Rhea J, Crouch ML, Mocek UM, Kittell PE, et al. Khan AU , 编. Isolation and characterization of antimicrobial compounds in plant extracts against multidrug-resistant Acinetobacter baumannii. PLOS ONE. 2013, 8 (4): e61594. Bibcode:2013PLoSO...861594M. PMC 3632535 . PMID 23630600. doi:10.1371/journal.pone.0061594.

[LiuChan2010-2] Liu X, Chan CB, Jang SW, Pradoldej S, Huang J, He K, et al. A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect. Journal of Medicinal Chemistry. December 2010, 53 (23): 8274–86. PMC 3150605 . PMID 21073191. doi:10.1021/jm101206p.

[1]

[2]