多塞平

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多塞平
臨床資料
商品名（英语：Drug nomenclature）Sinequan, Quitaxon, Adapin, Triadapin, Aponal, others
其他名稱NSC-108160
AHFS/Drugs.comMonograph
MedlinePlusa682390
核准狀況
懷孕分級
  • 澳: C
给药途径By mouth, topical, intravenous, intramuscular injection[1]
藥物類別（英语：Drug class）三环类抗抑郁药（TCA）
ATC碼
法律規範狀態
法律規範
藥物動力學數據
生物利用度13–45% (mean 29%)[2]
血漿蛋白結合率76%
药物代谢Hepatic (CYP2D6, CYP2C19)[2]
代謝產物Nordoxepin, glucuronide conjugates
生物半衰期Doxepin: 8–24 hours (mean 17 hours)
Nordoxepin: 28–31 hours
排泄途徑Urine: ~50%[2]
Feces: minor[2]
识别信息
  • (E/Z)-3-(dibenzo[b,e]oxepin-11(6H)-ylidene)-N,N-dimethylpropan-1-amine
CAS号1668-19-5（
1229-29-4 (hydrochloride)
3607-18-9 (cidoxepin)）  checkY
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
PDB配體ID
化学信息
化学式C19H21NO
摩尔质量279.38 g·mol−1
3D模型（JSmol（英语：JSmol））
  • CN(C)CC/C=C1C2=C(C=CC=C2)OCC3=C/1C=CC=C3
  • InChI=1S/C19H21NO/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19/h3-6,8-12H,7,13-14H2,1-2H3 checkY
  • Key:ODQWQRRAPPTVAG-UHFFFAOYSA-N checkY

多塞平（英語：Doxepin）是一种含氮有机化合物，化学式C19H21NO，属于三环类抗抑郁药（TCA）。[4][5]

参考文献[编辑]

  1. ^ Doxepin Hydrochloride. Martindale: The Complete Drug Reference. London, UK: Pharmaceutical Press. 30 January 2013 [3 December 2013]. 
  2. ^ 2.0 2.1 2.2 2.3 Lemke TL, Williams DA. Antidepressants. Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. 24 January 2012: 604–. ISBN 978-1-60913-345-0. 
  3. ^ Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control]. Diário Oficial da União. 2023-03-31 (2023-04-04) [2023-08-16]. （原始内容存档于2023-08-03） （巴西葡萄牙语）. 
  4. ^ Doxepin Hydrochloride. Drugs.com. American Society of Health-System Pharmacists. [20 March 2019]. 
  5. ^ Silenor (doxepin) label (PDF). FDA. 17 March 2010 [25 October 2017].  For label updates see FDA index page for NDA 022036

外部链接[编辑]

  • Doxepin. Drug Information Portal. U.S. National Library of Medicine. 
  • Doxepin hydrochloride. Drug Information Portal. U.S. National Library of Medicine. 
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