尿激酶受體

尿激酶受體
已知的結構
PDB	直系同源搜尋: PDBe RCSB
PDBID列表
	1YWH、2FD6、3BT1、3BT2、3U73、3U74、2I9B、4K24、4QTI
識別號
別名	PLAUR；, CD87, U-PAR, UPAR, URKR, plasminogen activator, urokinase receptor
外部ID	OMIM：173391 MGI：97612 HomoloGene：48120 GeneCards：PLAUR
基因位置（人類）
染色體	19號染色體
終止	43,670,547 bp
基因位置（小鼠）
染色體	小鼠7號染色體
終止	24,175,393 bp
RNA表達模式
	; ; ; ;
	查閱更多表達數據
基因本體
分子功能	• protein domain specific binding; • 血漿蛋白結合; • urokinase plasminogen activator receptor activity; • 酶結合; • signaling receptor binding; • signaling receptor activity;
細胞組分	• integral component of membrane; • cell projection; • endoplasmic reticulum lumen; • endoplasmic reticulum membrane; • 膜; • 粘着斑; • integral component of plasma membrane; • 細胞外區域; • 細胞連接; • anchored component of membrane; • 外排體; • extrinsic component of membrane; • 細胞膜; • specific granule membrane; • cell surface;
生物學過程	• positive regulation of protein phosphorylation; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; • 纖溶作用; • negative regulation of intrinsic apoptotic signaling pathway; • urokinase plasminogen activator signaling pathway; • negative regulation of apoptotic process; • 凝血; • 糖基磷脂酰肌醇化; • 趨化性; • positive regulation of release of cytochrome c from mitochondria; • positive regulation of DNA binding; • positive regulation of epidermal growth factor receptor signaling pathway; • regulation of proteolysis; • 信號轉導; • neutrophil degranulation;
	Sources:Amigo / QuickGO
直系同源
	5329
	18793
	ENSG00000011422
	ENSMUSG00000046223
	Q03405
	P35456
	NM_001005376; NM_001005377; NM_001301037; NM_002659
	NM_011113
	NP_001005376; NP_001005377; NP_001287966; NP_002650
	NP_035243
	維基數據
檢視/編輯人類	檢視/編輯小鼠

尿激酶受體（英語：Urokinase receptor，或稱為尿纖溶酶原活化物受體，縮寫uPAR,也稱為CD87，Cluster of Differentiation 87，分化簇87）是一種多結構域醣蛋白，通過糖磷脂酰肌醇（GPI）錨定在細胞膜上，最初被鑑定為尿激酶（尿纖溶酶原活化物，uPA）在細胞表面的飽和結合位點。uPAR在多種癌細胞表明都有發現^[5]。

參考文獻[編輯]

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000011422 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000046223 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Smith, HW; Marra, P; Marshall, CJ. uPAR promotes formation of the p130Cas-Crk complex to activate Rac through DOCK180.. The Journal of cell biology. 2008-08-25, 182 (4): 777–90. PMID 18725541. doi:10.1083/jcb.200712050.

外部連結[編輯]

醫學主題詞表（MeSH）：PLAUR+protein,+human
PDB中UniProt可用的所有結構資訊之概述：Q03405 (Human Urokinase plasminogen activator surface receptor) 在PDBe-KB（英語：PDBe-KB）。

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000011422 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000046223 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Smith, HW; Marra, P; Marshall, CJ. uPAR promotes formation of the p130Cas-Crk complex to activate Rac through DOCK180.. The Journal of cell biology. 2008-08-25, 182 (4): 777–90. PMID 18725541. doi:10.1083/jcb.200712050.

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