酸感應離子信道2基因

酸感應離子信道2基因
識別號
別名	ASIC2；, ACCN, ACCN1, ASIC2a, BNC1, BNaC1, MDEG, hBNaC1, acid sensing ion channel subunit 2
外部ID	OMIM：601784 MGI：1100867 HomoloGene：137202 GeneCards：ASIC2
為以下藥物的標靶
	氫正離子、阿米洛利、nafamostat
基因位置（人類）
染色體	17號染色體
終止	34,174,964 bp
基因位置（小鼠）
染色體	小鼠11號染色體
終止	81,859,283 bp
RNA表達模式
	查閱更多表達數據
基因本體
分子功能	• ion gated channel activity; • sodium channel activity; • ion channel activity; • 血漿蛋白結合; • cation channel activity; • ligand-gated sodium channel activity; • acid-sensing ion channel activity;
細胞組分	• integral component of membrane; • 膜; • 細胞膜; • 樹突棘; • integral component of plasma membrane; • 突觸; • neuronal cell body; • neuron projection;
生物學過程	• 化學性突觸傳遞; • positive regulation of synapse assembly; • peripheral nervous system development; • sodium ion transmembrane transport; • detection of mechanical stimulus involved in sensory perception; • sodium ion transport; • regulation of membrane potential; • regulation of ion transmembrane transport; • response to mechanical stimulus; • negative regulation of apoptotic process; • cation transport; • 聽覺; • sensory perception of sour taste; • ion transport; • cation transmembrane transport; • central nervous system development; • ion transmembrane transport; • regulation of vasoconstriction; • protein localization to synapse; • response to acidic pH; • 光轉換; • regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback;
	Sources:Amigo / QuickGO
直系同源
	40
	11418
	ENSG00000108684
	ENSMUSG00000020704
	Q16515
	Q925H0
	NM_183377; NM_001094
	NM_001034013; NM_007384
	NP_001085; NP_899233
	NP_001029185; NP_031410
	維基數據
檢視/編輯人類	檢視/編輯小鼠

酸感應離子信道2 (ASIC2)也稱為 氫離子敏感陽離子頻道1、神經元 (ACCN1)或 大腦鈉通道1 (BNaC1)是一個蛋白質，在人類中的編碼的ASIC2 基因. ASIC2基因是五個旁系同源基因編碼蛋白質，形成三聚酸感應離子頻道 (Asic)在哺乳動物。^[6] CDNA的這種基因第一個克隆在1996年。^[7]^[8]^[9]^[10] ASIC基因可以通過不同的拼接形成不同類型的蛋白質變體。

這些基因主要是在中央和周圍神經系統。

可以形成異三聚體渠道。^[11]^[12]

結構和功能[編輯]

這個基因編碼的成員ASIC家族的蛋白質。^[13] 其中有許多氨基酸殘留與保守的間隔。 TM的區域一般都是象徵作為TM1(克隆N端)和TM2(靠近C端).

孔道通過離子選擇性地流動，從外面到細胞質形成由三TM2地區的三聚體。^[6]

參考文獻[編輯]

^ 對Acid sensing ion channel subunit 2起作用的藥物；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000108684 - Ensembl, May 2017
^ ^3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000020704 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^6.0 ^6.1 ASIC and ENaC type sodium channels: Conformational states and the structures of the ion selectivity filters (PDF). FEBS Journal. 2017, 284 (4): 525–545 [2019-12-03]. PMID 27580245. doi:10.1111/febs.13840. （原始內容 (PDF)存檔於2019-05-02）. 引用錯誤：帶有name屬性「2017-Hanukoglu」的<ref>標籤用不同內容定義了多次
^ The human degenerin MDEG, an amiloride-sensitive neuronal cation channel, is localized on chromosome 17q11.2-17q12 close to the microsatellite D17S798. Genomics. Oct 1996, 37 (2): 269–70. PMID 8921408. doi:10.1006/geno.1996.0558.
^ Cloning and expression of a novel human brain Na+ channel. The Journal of Biological Chemistry. Apr 1996, 271 (14): 7879–82. PMID 8626462. doi:10.1074/jbc.271.14.7879.
^ The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans. The Journal of Biological Chemistry. May 1996, 271 (18): 10433–6. PMID 8631835. doi:10.1074/jbc.271.18.10433.
^ BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels. Proceedings of the National Academy of Sciences of the United States of America. Feb 1997, 94 (4): 1459–64. PMC 19813 . PMID 9037075. doi:10.1073/pnas.94.4.1459.
^ Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+. The Journal of Biological Chemistry. Sep 2000, 275 (37): 28519–25. PMID 10842183. doi:10.1074/jbc.M004114200.
^ The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel with novel properties. The Journal of Biological Chemistry. Nov 1997, 272 (46): 28819–22. PMID 9360943. doi:10.1074/jbc.272.46.28819.
^ Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases.. Gene. Jan 2016, 579 (2): 95–132. PMC 4756657 . PMID 26772908. doi:10.1016/j.gene.2015.12.061.

外部連結[編輯]

Human ASIC2 genome location and ASIC2 gene details page in the UCSC Genome Browser（英語：UCSC Genome Browser）.
Human BNC1 genome location and BNC1 gene details page in the UCSC Genome Browser（英語：UCSC Genome Browser）.

[1] 對Acid sensing ion channel subunit 2起作用的藥物；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000108684 - Ensembl, May 2017

[refGRCm38Ensembl-3] 3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000020704 - Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[2017-Hanukoglu-6] 6.0 ^6.1 ASIC and ENaC type sodium channels: Conformational states and the structures of the ion selectivity filters (PDF). FEBS Journal. 2017, 284 (4): 525–545 [2019-12-03]. PMID 27580245. doi:10.1111/febs.13840. （原始內容 (PDF)存檔於2019-05-02）. 引用錯誤：帶有name屬性「2017-Hanukoglu」的<ref>標籤用不同內容定義了多次

[pmid8921408-7] The human degenerin MDEG, an amiloride-sensitive neuronal cation channel, is localized on chromosome 17q11.2-17q12 close to the microsatellite D17S798. Genomics. Oct 1996, 37 (2): 269–70. PMID 8921408. doi:10.1006/geno.1996.0558.

[8] Cloning and expression of a novel human brain Na+ channel. The Journal of Biological Chemistry. Apr 1996, 271 (14): 7879–82. PMID 8626462. doi:10.1074/jbc.271.14.7879.

[9] The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans. The Journal of Biological Chemistry. May 1996, 271 (18): 10433–6. PMID 8631835. doi:10.1074/jbc.271.18.10433.

[10] BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels. Proceedings of the National Academy of Sciences of the United States of America. Feb 1997, 94 (4): 1459–64. PMC 19813 . PMID 9037075. doi:10.1073/pnas.94.4.1459.

[11] Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+. The Journal of Biological Chemistry. Sep 2000, 275 (37): 28519–25. PMID 10842183. doi:10.1074/jbc.M004114200.

[12] The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel with novel properties. The Journal of Biological Chemistry. Nov 1997, 272 (46): 28819–22. PMID 9360943. doi:10.1074/jbc.272.46.28819.

[2016-Hanukoglu-13] Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases.. Gene. Jan 2016, 579 (2): 95–132. PMC 4756657 . PMID 26772908. doi:10.1016/j.gene.2015.12.061.

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