5-氨基-1,3,4-噻二唑-2-硫酮

5-氨基-1,3,4-噻二唑-2-硫酮
別名	2-氨基-5-巰基-1,3,4-噻二唑
識別
CAS號	2349-67-9
性質
化學式	C2H3N3S2
摩爾質量	133.2 g·mol−1
外觀	黃色晶體
熔點	236—238 °C（509—511 K）（分解）
	若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。

5-氨基-1,3,4-噻二唑-2-硫酮是一種有機化合物，化學式為C₂H₃N₃S₂。它可由氨基硫脲（英語：Thiosemicarbazide）和二硫化碳在DMF中回流^[2]或碳酸鈉存在下於乙醇中回流^[3]反應得到。它和異氰酸苯酯反應，可以得到N-苯基-N'-(5-巰基-1,3,4-噻二唑-2-基)脲。^[4]它和丙炔酸甲酯在水中加熱反應，可以得到3-(5-氨基-1,3,4-噻二唑-2-硫基)丙烯酸甲酯。^[5]

參考文獻[編輯]

^ ^1.0 ^1.1 S. Talath, A.K. Gadad. Synthesis, antibacterial and antitubercular activities of some 7-[4-(5-amino-[1,3,4]thiadiazole-2-sulfonyl)-piperazin-1-yl] fluoroquinolonic derivatives. European Journal of Medicinal Chemistry. 2006-08, 41 (8): 918–924 [2023-02-27]. doi:10.1016/j.ejmech.2006.03.027. （原始內容存檔於2023-03-15）（英語）.
^ You-Ming Zhang, Ming-Xia Liu, Qi Lin, Qiao Li, Tai-Bao Wei. Mercapto Thiadiazole-based Sensors with High Selectivity and Sensitivity for Hg 2 + in Aqueous Solution. Journal of Chemical Research. 2010-11, 34 (11): 619–621 [2023-02-27]. ISSN 1747-5198. doi:10.3184/030823410X12876712319282. （原始內容存檔於2023-02-26）（英語）.
^ Vaibhav Dubey, Manish Pathak, Hans R. Bhat, Udaya P. Singh. Design, Facile Synthesis, and Antibacterial Activity of Hybrid 1,3,4-thiadiazole-1,3,5-triazine Derivatives Tethered via -S- Bridge: Antibacterial Activity of 1,3,5-triazines. Chemical Biology & Drug Design. 2012-10, 80 (4): 598–604 [2023-02-27]. doi:10.1111/j.1747-0285.2012.01433.x. （原始內容存檔於2023-02-26）（英語）.
^ Mohammad M. Al-Sanea, Abdelrahman Hamdi, Simone Brogi, Samar S. Tawfik, Dina I. A. Othman, Mahmoud Elshal, Hidayat Ur Rahman, Della G. T. Parambi, Rehab M. Elbargisy, Samy Selim, Ehab M. Mostafa, Ahmed A. B. Mohamed. Design, synthesis, and biological investigation of oxadiazolyl, thiadiazolyl, and pyrimidinyl linked antipyrine derivatives as potential non-acidic anti-inflammatory agents. Journal of Enzyme Inhibition and Medicinal Chemistry. 2023-12-31, 38 (1) [2023-02-27]. ISSN 1475-6366. doi:10.1080/14756366.2022.2162511. （原始內容存檔於2023-02-26）（英語）.
^ Haiying Wang, Jiewei Rong. An Efficient Catalyst-Free Synthesis of Vinyl Sulfides in Aqueous-Phase. HETEROCYCLES. 2022, 104 (12) [2023-02-27]. ISSN 0385-5414. doi:10.3987/COM-22-14736. （原始內容存檔於2023-02-26）（英語）.

[Talath-1] 1.0 ^1.1 S. Talath, A.K. Gadad. Synthesis, antibacterial and antitubercular activities of some 7-[4-(5-amino-[1,3,4]thiadiazole-2-sulfonyl)-piperazin-1-yl] fluoroquinolonic derivatives. European Journal of Medicinal Chemistry. 2006-08, 41 (8): 918–924 [2023-02-27]. doi:10.1016/j.ejmech.2006.03.027. （原始內容存檔於2023-03-15）（英語）.

[2] You-Ming Zhang, Ming-Xia Liu, Qi Lin, Qiao Li, Tai-Bao Wei. Mercapto Thiadiazole-based Sensors with High Selectivity and Sensitivity for Hg 2 + in Aqueous Solution. Journal of Chemical Research. 2010-11, 34 (11): 619–621 [2023-02-27]. ISSN 1747-5198. doi:10.3184/030823410X12876712319282. （原始內容存檔於2023-02-26）（英語）.

[3] Vaibhav Dubey, Manish Pathak, Hans R. Bhat, Udaya P. Singh. Design, Facile Synthesis, and Antibacterial Activity of Hybrid 1,3,4-thiadiazole-1,3,5-triazine Derivatives Tethered via -S- Bridge: Antibacterial Activity of 1,3,5-triazines. Chemical Biology & Drug Design. 2012-10, 80 (4): 598–604 [2023-02-27]. doi:10.1111/j.1747-0285.2012.01433.x. （原始內容存檔於2023-02-26）（英語）.

[4] Mohammad M. Al-Sanea, Abdelrahman Hamdi, Simone Brogi, Samar S. Tawfik, Dina I. A. Othman, Mahmoud Elshal, Hidayat Ur Rahman, Della G. T. Parambi, Rehab M. Elbargisy, Samy Selim, Ehab M. Mostafa, Ahmed A. B. Mohamed. Design, synthesis, and biological investigation of oxadiazolyl, thiadiazolyl, and pyrimidinyl linked antipyrine derivatives as potential non-acidic anti-inflammatory agents. Journal of Enzyme Inhibition and Medicinal Chemistry. 2023-12-31, 38 (1) [2023-02-27]. ISSN 1475-6366. doi:10.1080/14756366.2022.2162511. （原始內容存檔於2023-02-26）（英語）.

[5] Haiying Wang, Jiewei Rong. An Efficient Catalyst-Free Synthesis of Vinyl Sulfides in Aqueous-Phase. HETEROCYCLES. 2022, 104 (12) [2023-02-27]. ISSN 0385-5414. doi:10.3987/COM-22-14736. （原始內容存檔於2023-02-26）（英語）.

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