硫代硫酸金钠

**硫代硫酸金钠**
临床资料
给药途径	肌肉注射
ATC码	M01CB02 (WHO) ;
识别信息
	IUPAC命名法 trisodium dithiosulphate aurate(I), dihydrate; ;
CAS号	15283-45-1
PubChem CID	170028;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID90939916 ;
化学信息
化学式	AuNa3O6S4
摩尔质量	332.08452 g/mol

硫代硫酸金钠（英语：Sodium aurothiosulfate）是化学式为Na₃Au(S₂O₃)₂·2H₂O的无机化合物，其阴离子是由一个金原子和二个硫代硫酸根离子配位而成的直线形离子^[1]^[2]。硫代硫酸金钠和其他的金化合物一样，可以做为抗风湿药（英语：Antirheumatic）^[3]。第一次的安慰剂对照实验可能是在1931年开始的，当时用sanocrysin治疗结核病，以蒸馏水安慰剂比较其效果^[4]。

结构[编辑]

Na
3[Au(S
2O
3)
2] · 2H₂O在X射线晶体学下的结构。红色：氧、橘色：金、黄色：硫、紫色：钠。氢原子省略不画

其离子错合物的结构是线性的AuS2中心，整体是中心对称结构。和其他过渡金属硫代硫酸盐（英语：thiosulfate complex）类似，硫代硫酸根中只有部分planetary的硫原子会和金属配位^[5]^[6]^[7]。

参考资料[编辑]

^ Baggio, R. Crystal and molecular structure of trisodium dithiosulphate aurate(I), dihydrate, Na3[Au(S2O3)2],2H2O. Journal of Inorganic and Nuclear Chemistry. 1973, 35 (9): 3191. doi:10.1016/0022-1902(73)80019-3.
^ Tobön-Zapata, G. Vibrational spectrum of Sanocrysin. Spectrochimica Acta Part a Molecular and Biomolecular Spectroscopy. 1997, 53 (2): 183. doi:10.1016/S1386-1425(97)83024-7.
^ Shaw, III, C. F. Gold-Based Therapeutic Agents. Chemical Reviews. 1999, 99 (9): 2589–600. PMID 11749494. doi:10.1021/cr980431o.
^ Ethical and regulatory aspects of clinical research: readings and commentary, Ezekiel J. Emanuel, Johns Hopkins University Press, 2003, p 140
^ Baggio RF, Baggio S. Crystal and molecular structure of trisodium dithiosulphate aurate(I), dihydrate, Na₃[Au(S₂O₃)₂],2H₂O. Journal of Inorganic and Nuclear Chemistry. 1973, 35 (9): 3191–3200. doi:10.1016/0022-1902(73)80019-3.
^ Tobön-Zapata G, Etcheverry SB, Baran EJ. Vibrational spectrum of Sanocrysin. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 1997, 53 (2): 183–188. Bibcode:1997AcSpA..53..183T. doi:10.1016/S1386-1425(97)83024-7.
^ Ruben, Helena.; Zalkin, Allan.; Faltens, Marjorie O.; Templeton, David H. Crystal structure of sodium gold(I) thiosulfate dihydrate, Na3Au(S2O3)2.2H2O. Inorganic Chemistry. 1974, 13 (8): 1836–1839. doi:10.1021/ic50138a011.

[1] Baggio, R. Crystal and molecular structure of trisodium dithiosulphate aurate(I), dihydrate, Na3[Au(S2O3)2],2H2O. Journal of Inorganic and Nuclear Chemistry. 1973, 35 (9): 3191. doi:10.1016/0022-1902(73)80019-3.

[2] Tobön-Zapata, G. Vibrational spectrum of Sanocrysin. Spectrochimica Acta Part a Molecular and Biomolecular Spectroscopy. 1997, 53 (2): 183. doi:10.1016/S1386-1425(97)83024-7.

[shaw-3] Shaw, III, C. F. Gold-Based Therapeutic Agents. Chemical Reviews. 1999, 99 (9): 2589–600. PMID 11749494. doi:10.1021/cr980431o.

[4] Ethical and regulatory aspects of clinical research: readings and commentary, Ezekiel J. Emanuel, Johns Hopkins University Press, 2003, p 140

[5] Baggio RF, Baggio S. Crystal and molecular structure of trisodium dithiosulphate aurate(I), dihydrate, Na₃[Au(S₂O₃)₂],2H₂O. Journal of Inorganic and Nuclear Chemistry. 1973, 35 (9): 3191–3200. doi:10.1016/0022-1902(73)80019-3.

[6] Tobön-Zapata G, Etcheverry SB, Baran EJ. Vibrational spectrum of Sanocrysin. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 1997, 53 (2): 183–188. Bibcode:1997AcSpA..53..183T. doi:10.1016/S1386-1425(97)83024-7.

[Zalkin-7] Ruben, Helena.; Zalkin, Allan.; Faltens, Marjorie O.; Templeton, David H. Crystal structure of sodium gold(I) thiosulfate dihydrate, Na3Au(S2O3)2.2H2O. Inorganic Chemistry. 1974, 13 (8): 1836–1839. doi:10.1021/ic50138a011.

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