Fel d 1

Fel d 1
	存在於貓唾液中的主要過敏原——Fel d 1二聚體的晶體結構
識別
符號	CH2
替換符號	Fel d I, AG4, Allergen Cat-1
Entrez	677879
PDB	1PUO
UniProt	P30440
其他資料

Fel d 1（Felis domesticus allergen 1^[2]）是貓的一種蛋白質，由CH2基因編碼^[3]^[4]。Fel d 1主要在貓的唾液腺和皮脂腺中分泌，是存在於貓身上的主要過敏原。目前尚未清楚這種蛋白質在動物體內的作用，但它能引起敏感人群對lgG或lgE作出過敏反應或哮喘反應。

降低家居Fed d 1含量的可行方法有移開柔軟表面（地毯）、經常洗床單、洗高效濾網和為貓洗澡。Fel d 1是一種特別粘的蛋白質，已被證明能粘在衣物和人的毛髮中，而且在貓從未出現過的地方也能檢測得到。

貓平均每天產生2-7微克的Fel d 1。研究也發現未被閹割的公貓的Fel d 1的產量較被閹割的公貓多，這也導致一個假設的產生，假設認為Fel d 1是由睪酮激素調控的。被閹割的公貓的Fed d 1產量和母貓相近，而未被閹割的母貓的Fel d 1的產量也與被閹割的母貓的相近。儘管母貓和被閹割的公貓的Fel d 1產量低，但也足以引發敏感人群的過敏反應。

Fel d 1是一種分子量有18 kDa的異源二聚體蛋白質^[2]。

參考文獻[編輯]

^ PDB 1PUO; Kaiser L, Grönlund H, Sandalova T, Ljunggren HG, van Hage-Hamsten M, Achour A, Schneider G. The crystal structure of the major cat allergen Fel d 1, a member of the secretoglobin family. J. Biol. Chem. September 2003, 278 (39): 37730–5. PMID 12851385. doi:10.1074/jbc.M304740200.
^ ^2.0 ^2.1 Natural Fel d 1 (PDF). INDOOR Biotechnologies. [2011-07-13]. ^{[永久失效連結]}
^ Morgenstern JP, Griffith IJ, Brauer AW, Rogers BL, Bond JF, Chapman MD, Kuo MC. Amino acid sequence of Fel dI, the major allergen of the domestic cat: protein sequence analysis and cDNA cloning. Proc. Natl. Acad. Sci. U.S.A. November 1991, 88 (21): 9690–4. PMC 52784 . PMID 1946388.
^ Griffith IJ, Craig S, Pollock J, Yu XB, Morgenstern JP, Rogers BL. Expression and genomic structure of the genes encoding FdI, the major allergen from the domestic cat. Gene. April 1992, 113 (2): 263–8. PMID 1572548.

參見[編輯]

[pmid12851385-1] PDB 1PUO; Kaiser L, Grönlund H, Sandalova T, Ljunggren HG, van Hage-Hamsten M, Achour A, Schneider G. The crystal structure of the major cat allergen Fel d 1, a member of the secretoglobin family. J. Biol. Chem. September 2003, 278 (39): 37730–5. PMID 12851385. doi:10.1074/jbc.M304740200.

[INDOOR-2] 2.0 ^2.1 Natural Fel d 1 (PDF). INDOOR Biotechnologies. [2011-07-13]. ^{[永久失效連結]}

[pmid1946388-3] Morgenstern JP, Griffith IJ, Brauer AW, Rogers BL, Bond JF, Chapman MD, Kuo MC. Amino acid sequence of Fel dI, the major allergen of the domestic cat: protein sequence analysis and cDNA cloning. Proc. Natl. Acad. Sci. U.S.A. November 1991, 88 (21): 9690–4. PMC 52784 . PMID 1946388.

[pmid1572548-4] Griffith IJ, Craig S, Pollock J, Yu XB, Morgenstern JP, Rogers BL. Expression and genomic structure of the genes encoding FdI, the major allergen from the domestic cat. Gene. April 1992, 113 (2): 263–8. PMID 1572548.

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