依决洛单抗

依决洛单抗（INN：Edrecolomab；开发代号：MAb17-1A，商品名Panorex），或译依屈洛单抗，是一种小鼠单克隆抗体，靶向细胞表面糖蛋白 EpCAM（17-1A），该蛋白在上皮组织和各种癌症上表达。

初步研究表明，该药物有望应用于III期结直肠癌（伴有淋巴结转移）患者。^[1]^[2]不过，尚未证明对II期结肠癌（局部晚期癌症但未蔓延到淋巴结）有任何效果。^[3]

依决洛单抗在这些研究中具有良好的耐受性，因此此类研究现在集中于它是否可以用于其他形式的癌症。

参考资料[编辑]

^ Riethmüller G, Schneider-Gädicke E, Schlimok G, Schmiegel W, Raab R, Höffken K, et al. Randomised trial of monoclonal antibody for adjuvant therapy of resected Dukes' C colorectal carcinoma. German Cancer Aid 17-1A Study Group. Lancet. May 1994, 343 (8907): 1177–83. PMID 7909866. S2CID 45574458. doi:10.1016/s0140-6736(94)92398-1.
^ Punt CJ, Nagy A, Douillard JY, Figer A, Skovsgaard T, Monson J, et al. Edrecolomab alone or in combination with fluorouracil and folinic acid in the adjuvant treatment of stage III colon cancer: a randomised study. Lancet. August 2002, 360 (9334): 671–7. PMID 12241873. S2CID 42391189. doi:10.1016/S0140-6736(02)09836-7.
^ Colacchio TA, Niedzwiecki D, Compton C, Warren R, Benson AI, Goldberg R, Kerr D, Fields A, Hollis D, Mayer R. Phase III trial of adjuvant immunotherapy with MOAb 17–1A following resection for stage II adenocarcinoma of the colon (CALGB 9581). Journal of Clinical Oncology. July 2004, 22 (14_suppl): 3522. doi:10.1200/jco.2004.22.90140.3522.