利洛司酮

编辑链接
维基百科，自由的百科全书
利洛司酮
臨床資料
其他名稱ZK-98734、ZK-734
识别信息
  • (8S,11R,13S,14S,17R)-11-[4-(dimethylamino)phenyl]-17-hydroxy-17-[(Z)-3-hydroxyprop-1-enyl]-13-methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
CAS号97747-88-1
PubChem CID
ChemSpider
UNII
ChEMBL
化学信息
化学式C29H37NO3
摩尔质量447.62 g·mol−1
3D模型（JSmol（英语：JSmol））
  • C[C@]12C[C@@H](C3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CC[C@]2(/C=C\CO)O)C5=CC=C(C=C5)N(C)C
  • InChI=1S/C29H37NO3/c1-28-18-25(19-5-8-21(9-6-19)30(2)3)27-23-12-10-22(32)17-20(23)7-11-24(27)26(28)13-15-29(28,33)14-4-16-31/h4-6,8-9,14,17,24-26,31,33H,7,10-13,15-16,18H2,1-3H3/b14-4-/t24-,25+,26-,28-,29-/m0/s1
  • Key:RCOWGILQXUPXEW-FUSOFXSQSA-N

利洛司酮（INN：liropristone；开发代号：ZK-98734、ZK-734）是一种合成类甾体抗孕激素（英语：Antiprogestogen），具有额外的抗糖皮质激素（英语：Antiglucocorticoid）活性。该药物由先灵公司（英语：Schering AG）开发，于1985年获得专利。[1][2][3][4]它被描述为一种堕胎药（英语：abortifacient）和子宫内膜避孕药（英语：Hormonal contraception）。[1][4][5]该药物与米非司酮的不同之处仅在于其C17α侧链的结构，据说相比之下，其抗糖皮质激素活性大大降低。[6]

参考资料[编辑]

  1. ^ 1.0 1.1 Elks J. The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014: 733–. ISBN 978-1-4757-2085-3. 
  2. ^ Rao KA. Textbook of Gynaecology. Elsevier India. November 2009: 187–. ISBN 978-81-312-1526-5. 
  3. ^ Baird DT, Schütz G, Krattenmacher R. Organ-Selective Actions of Steroid Hormones. Springer Science & Business Media. 9 March 2013: 108–. ISBN 978-3-662-09153-1. 
  4. ^ 4.0 4.1 Milne GW. Drugs: Synonyms and Properties: Synonyms and Properties. Taylor & Francis. 8 May 2018: 23–. ISBN 978-1-351-78989-9. 
  5. ^ Deshpande H. Practical Management of Ovulation Induction. JP Medical Ltd. 12 February 2016: 29–. ISBN 978-93-5250-028-4. 
  6. ^ Van Look PF, Pérez-Palacios G, World Health Organization . Contraceptive research and development, 1984 to 1994: the road from Mexico City to Cairo and beyond. Oxford University Press. 1994: 169. ISBN 978-0-19-563630-7. [...] lilopristone, which differs from mifepristone only in the structure of the 17a side chain, is said to have a much reduced antiglucocorticoid activity (Neef et al., 1984). 

延伸阅读[编辑]

  • Puri CP, Katkam RR, D'Souza A, Elger WA, Patil RK. Effects of progesterone antagonist, lilopristone (ZK 98.734), on induction of menstruation, inhibition of nidation, and termination of pregnancy in bonnet monkeys. Biology of Reproduction. September 1990, 43 (3): 437–43. PMID 2271724. doi:10.1095/biolreprod43.3.437 可免费查阅. 
  • Puri CP, Patil RK, Kholkute SD, Elger WA, Swamy XR. Progesterone antagonist lilopristone: a potent abortifacient in the common marmoset. American Journal of Obstetrics and Gynecology. July 1989, 161 (1): 248–53. PMID 2502015. doi:10.1016/0002-9378(89)90274-3. 
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