志賀毒素

現有可用的蛋白結構：
Pfam	結構（旧版） / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum（英语：PDBsum）	結構概要

志賀样毒素beta亚基
鑑定
標誌	SLT_beta
Pfam	PF02258（旧版）
InterPro（英语：InterPro）	IPR003189
SCOP（英语：Structural Classification of Proteins）	2bos / SUPFAM
TCDB（英语：TCDB）	1.C.54
現有可用的蛋白結構：
Pfam	結構（旧版） / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum（英语：PDBsum）	結構概要

志賀样毒素alpha亚基
鑑定
標誌	SLT_alpha
InterPro（英语：InterPro）	IPR016331
SCOP（英语：Structural Classification of Proteins）	1r4q / SUPFAM

志賀毒素（英語：Shiga toxin，簡寫為STX）是由志賀氏菌屬等细菌所分泌的外毒素，由α和β亚基組合而成，位于细菌基因组的原噬菌体段^[1]，这一蛋白最早由志賀潔发现^[2]。过去常把大腸桿菌分泌的志賀毒素称为志賀样毒素（Shiga-like toxin，SLT），但现在这一词已不常用，能产生志賀毒素的大腸桿菌有O157:H7型和O104:H4型等^[3]^[4]^[5]。

参考文献[编辑]

^ Friedman D; Court D. Bacteriophage lambda: alive and well and still doing its thing. Current Opinion in Microbiology. 2001, 4 (2): 201–7. PMID 11282477. doi:10.1016/S1369-5274(00)00189-2.
^ Trofa, Andrew F.; Ueno-Olsen, Hannah; Oiwa, Ruiko; Yoshikawa, Masanosuke. Dr. Kiyoshi Shiga: Discoverer of the Dysentery Bacillus. Clinical Infectious Diseases. 1999-11-01, 29 (5): 1303–1306. ISSN 1058-4838. PMID 10524979. doi:10.1086/313437  （英语）.
^ Zhu Q; Li L; Guo Z; Yang R. Identification of Shiga-like toxin Escherichia coli isolated from children with diarrhea by polymerase chain reaction. Chin. Med. J. June 2002, 115 (6): 815–8. PMID 12123543.
^ Beutin L. Emerging enterohaemorrhagic Escherichia coli, causes and effects of the rise of a human pathogen. Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health. 2006, 53 (7): 299–305. PMID 16930272. doi:10.1111/j.1439-0450.2006.00968.x.
^ Spears; et al. A comparison of Enteropathogenic and enterohaemorragic E.coli pathogenesis. FEMS Microbiology Letters. 2006, 255 (2): 187–202. PMID 16448495. doi:10.1111/j.1574-6968.2006.00119.x .

[Friedman_2001-1] Friedman D; Court D. Bacteriophage lambda: alive and well and still doing its thing. Current Opinion in Microbiology. 2001, 4 (2): 201–7. PMID 11282477. doi:10.1016/S1369-5274(00)00189-2.

[shiga-nom-2] Trofa, Andrew F.; Ueno-Olsen, Hannah; Oiwa, Ruiko; Yoshikawa, Masanosuke. Dr. Kiyoshi Shiga: Discoverer of the Dysentery Bacillus. Clinical Infectious Diseases. 1999-11-01, 29 (5): 1303–1306. ISSN 1058-4838. PMID 10524979. doi:10.1086/313437  （英语）.

[pmid12123543-3] Zhu Q; Li L; Guo Z; Yang R. Identification of Shiga-like toxin Escherichia coli isolated from children with diarrhea by polymerase chain reaction. Chin. Med. J. June 2002, 115 (6): 815–8. PMID 12123543.

[Beutin_2006-4] Beutin L. Emerging enterohaemorrhagic Escherichia coli, causes and effects of the rise of a human pathogen. Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health. 2006, 53 (7): 299–305. PMID 16930272. doi:10.1111/j.1439-0450.2006.00968.x.

[5] Spears; et al. A comparison of Enteropathogenic and enterohaemorragic E.coli pathogenesis. FEMS Microbiology Letters. 2006, 255 (2): 187–202. PMID 16448495. doi:10.1111/j.1574-6968.2006.00119.x .

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