甲氯喹酮

**甲氯喹酮**
臨床資料
商品名（英语：Drug nomenclature）	Nubarene; Casfen
ATC碼	未分配;
法律規範狀態
法律規範	加：Schedule III; 德：Anlage I; 英：Class B; 美：附表I; UN：Psychotropic Schedule II;
识别信息
	IUPAC命名法 3-(2-chlorophenyl)-2-methylquinazolin-4(3H)-one; ;
CAS号	340-57-8
PubChem CID	9567;
ChemSpider	9192 ;
UNII	09XU4VDV7E;
KEGG	D04877 ;
ChEMBL	ChEMBL279960 ;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID7048875 ;
ECHA InfoCard	100.005.848
化学信息
化学式	C15H11ClN2O
摩尔质量	270.714
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES Clc3ccccc3N/1C(=O)c2c(\N=C\1C)cccc2;
	InChI InChI=1S/C15H11ClN2O/c1-10-17-13-8-4-2-6-11(13)15(19)18(10)14-9-5-3-7-12(14)16/h2-9H,1H3 ; Key:SFITWQDBYUMAPS-UHFFFAOYSA-N ;

甲氯喹酮（英语：Mecloqualone）是一种喹唑啉酮类GABA能，是甲喹酮的类似物，于1960年首次生产，^[1]主要在法国和其他一些欧洲国家销售。由于其对GABA_A受体的β亚型的激动剂活性，它具有镇静、催眠和抗焦虑的特性，并用于治疗失眠。^[2]甲氯喹酮比甲喹酮起效更快但持续时间更短，因此仅用作安眠药，^[3]而甲喹酮也可用作通用抗焦虑药。甲氯喹酮从未像甲喹酮那样广泛使用，并且由于担心其可能被滥用和过量服用而不再开处方。在美国，它是一种附表I非麻醉（镇静）受控物质，ACSCN为2572，年度总制造配额为30克。^[4]

参见[编辑]

参考资料[编辑]

^ Jackman GB, Petrow V, Stephenson O. Some 2, 3-disubstituted 3H-4-quinazolones and 3H-4-thioquinazolones. The Journal of Pharmacy and Pharmacology. September 1960, 12: 529–38. PMID 14406263. S2CID 31254238. doi:10.1111/j.2042-7158.1960.tb12705.x.
^ Mouren P, Giraud F, Pinsard N. [Clinical use of a new psycholeptic: Mecloqualone]. Marseille Medical. 1963, 100: 599–602. PMID 13936358.
^ Dubnk B, Towne CA, Bush MT. Detection, assay and rate of excretion of mecloqualone in animals and man. Toxicology and Applied Pharmacology. November 1969, 15 (3): 632–41. PMID 5353825. doi:10.1016/0041-008X(69)90065-9.
^ Established Aggregate Production Quotas for Schedule I and II Controlled Substances and Assessment of Annual Needs for the List I Chemicals Ephedrine, Pseudoephedrine, and Phenylpropanolamine for 2022. [2023-03-30]. （原始内容存档于2021-12-06）.

[1] Jackman GB, Petrow V, Stephenson O. Some 2, 3-disubstituted 3H-4-quinazolones and 3H-4-thioquinazolones. The Journal of Pharmacy and Pharmacology. September 1960, 12: 529–38. PMID 14406263. S2CID 31254238. doi:10.1111/j.2042-7158.1960.tb12705.x.

[2] Mouren P, Giraud F, Pinsard N. [Clinical use of a new psycholeptic: Mecloqualone]. Marseille Medical. 1963, 100: 599–602. PMID 13936358.

[3] Dubnk B, Towne CA, Bush MT. Detection, assay and rate of excretion of mecloqualone in animals and man. Toxicology and Applied Pharmacology. November 1969, 15 (3): 632–41. PMID 5353825. doi:10.1016/0041-008X(69)90065-9.

[4] Established Aggregate Production Quotas for Schedule I and II Controlled Substances and Assessment of Annual Needs for the List I Chemicals Ephedrine, Pseudoephedrine, and Phenylpropanolamine for 2022. [2023-03-30]. （原始内容存档于2021-12-06）.

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