粉防己碱
| 粉防己碱 | |
|---|---|
| |
| IUPAC名 9,20,21,25-tetramethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.2³,⁶.1⁸,¹².1¹⁴,¹⁸.0²⁷,³¹.0²²,³³]hexatriaconta-3,5,8(34),9,11,18,20,22(33),24(32),25,27(31),35-dodecaene | |
| 识别 | |
| CAS号 | 518-34-3 
|
| PubChem | 73078 |
| SMILES |
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| 性质 | |
| 化学式 | C38H42N2O6 |
| 摩尔质量 | 622.74988 g·mol⁻¹ |
| 若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。 | |
粉防己碱（tetrandrine，fanchinine，hanfangchin A）是一种双苄基异喹啉生物碱，属一种钙通道阻滞剂。具有抗炎，免疫和抗过敏作用，抑制肥大细胞的脱粒。 它具有“类奎尼丁”的抗心律失常作用。已可从粉防己[1]和其他中草药中分离出来。 具有血管扩张特性，因此可以降低血压。[2]粉防己碱可能具有治疗肝病[3]和肝癌的潜在用途。 [4][5][6]具有预防小梁切除术后结膜炎或严重结膜炎症患者过度瘢痕/纤维化的潜在治疗价值。[7]粉防己碱具有抗炎和抗纤维化作用，使得粉防己碱和相关化合物可用于治疗肺矽肺病，肝硬化和类风湿性关节炎。[2]还表明粉防己碱在体外抑制埃博拉病毒进入宿主细胞，并且在对小鼠的初步研究中显示出对抗埃博拉病毒的治疗功效。[8]
生物合成[编辑]
粉防己碱是由S-N-甲基乌药碱的自由基偶联二聚化生物合成的：[9]
同义词[编辑]
其同义词包括防己碱、汉防己碱A、NSC 77037、(S ,S )-(+)-粉防己碱、青藤碱A、TTD、四联蛋白和d-粉防己碱。[10]
参考文献[编辑]
- ^ Zhang, Lijin; Geng, Yanling; Duan, Wenjuan; Wang, Daijie; Fu, Maorun; Wang, Xiao. Ionic liquid-based ultrasound-assisted extraction of fangchinoline and tetrandrine from Stephaniae tetrandrae. Journal of Separation Science. 2009-10, 32 (20): 3550–3554 [2021-11-10]. ISSN 1615-9314. PMID 19764054. doi:10.1002/jssc.200900413. （原始内容存档于2022-06-17）.
- ^ 2.0 2.1 Kwan, Chiu-Yin; Achike, F. I. Tetrandrine and related bis-benzylisoquinoline alkaloids from medicinal herbs: cardiovascular effects and mechanisms of action. Acta Pharmacologica Sinica. 2002-12, 23 (12): 1057–1068 [2021-11-10]. ISSN 1671-4083. PMID 12466042. （原始内容存档于2022-07-04）.
- ^ Feng, Dechun; Mei, Yunhua; Wang, Ying; Zhang, Bianhong; Wang, Chen; Xu, Lingyun. Tetrandrine protects mice from concanavalin A-induced hepatitis through inhibiting NF-kappaB activation. Immunology Letters. 2008-12-22, 121 (2): 127–133 [2021-11-10]. ISSN 1879-0542. PMID 18992279. doi:10.1016/j.imlet.2008.10.001. （原始内容存档于2021-11-10）.
- ^ Liu, Chaoyang; Gong, Ke; Mao, Xin; Li, Wenhua. Tetrandrine induces apoptosis by activating reactive oxygen species and repressing Akt activity in human hepatocellular carcinoma. International Journal of Cancer. 2011-09-15, 129 (6): 1519–1531 [2021-11-10]. ISSN 1097-0215. PMID 21128229. doi:10.1002/ijc.25817. （原始内容存档于2021-11-10）.
- ^ Cheng, Zhixiang; Wang, Keming; Wei, Jia; Lu, Xiang; Liu, Baorui. Proteomic analysis of anti-tumor effects by tetrandrine treatment in HepG2 cells. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology. 2010-11, 17 (13): 1000–1005 [2021-11-10]. ISSN 1618-095X. PMID 20554191. doi:10.1016/j.phymed.2010.03.018. （原始内容存档于2021-11-10）.
- ^ Deng, Wen-Ying; Luo, Su-Xia; Zhou, Meng-Qiang; Li, Ning; Chen, Xiao-Bing; Han, Li-Li. [The study of anti-tumor effect of Tetrandrine combined with Nedaplatin on human liver cancer cell line 7402]. Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials. 2008-10, 31 (10): 1522–1525 [2021-11-10]. ISSN 1001-4454. PMID 19230406. （原始内容存档于2021-11-10）.
- ^ Kitano, Ai; Yamanaka, Osamu; Ikeda, Kazuo; Ishida-Nishikawa, Iku; Okada, Yuka; Shirai, Kumi; Saika, Shizuya. Tetrandrine suppresses activation of human subconjunctival fibroblasts in vitro. Current Eye Research. 2008-07, 33 (7): 559–565 [2021-11-10]. ISSN 1460-2202. PMID 18600488. doi:10.1080/02713680802220817. （原始内容存档于2022-06-15）.
- ^ Sakurai, Yasuteru; Kolokoltsov, Andrey A.; Chen, Cheng-Chang; Tidwell, Michael W.; Bauta, William E.; Klugbauer, Norbert; Grimm, Christian; Wahl-Schott, Christian; Biel, Martin. Two pore channels control Ebolavirus host cell entry and are drug targets for disease treatment. Science (New York, N.Y.). 2015-02-27, 347 (6225): 995–998 [2021-11-10]. ISSN 0036-8075. PMC 4550587
. PMID 25722412. doi:10.1126/science.1258758. （原始内容存档于2022-06-21）.
- ^ Bhakuni, Dewan S.; Jain, Sudha; Singh, Awadhesh N. Biosynthesis of the bisbenzylisoquinoline alkaloid, tetrandrine. Phytochemistry. 1980-01-01, 19 (11): 2347–2350. ISSN 0031-9422. doi:10.1016/S0031-9422(00)91024-0 （英语）.
- ^ Tetrandrine (NSC-77037) | ≥99%(HPLC) | Selleck | Calcium Channel inhibitor. selleckchem.com. [2021-11-10]. （原始内容存档于2021-11-10）.
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