飢餓反應
飢餓反應（starvation response）是動物（包括人類）的一組適應性生化和生理變化，由缺乏食物或極度體重減輕引發，其中身體試圖通過減少燃燒的卡路里量來節省能量[1]。當營養物質有限時，細菌會對抗生素產生高度耐受性。飢餓有助於感染期間的抗生素耐受性，因為當營養物質被宿主防禦隔離並被增殖細菌消耗時，營養物質變得有限[2][3]。體內飢餓誘導耐受的最重要原因之一是生物膜生長，這發生在許多慢性感染中[4][5][6]。生物膜中的飢餓是由於位於生物膜簇外圍的細胞消耗營養以及減少底物通過生物膜的擴散[7]。生物膜細菌對幾乎所有抗生素類別都表現出極強的耐受性，提供限制性底物可以恢復敏感性[8]。
參考文獻[编辑]
- ^ Is Starvation Mode Real or Imaginary? A Critical Look. healthline. June 19, 2021 [2022-07-26]. （原始内容存档于2022-07-26）.
- ^ McDERMOTT, W. Microbial persistence.. The Yale Journal of Biology and Medicine. February 1958, 30 (4): 257–91. PMC 2603844
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- ^ McCune, Robert M.; Dineen, Paul A. Peter; Batten, John C. The Effect of Antimicrobial Drugs on an Experimental Staphylococcal Infection in Mice. Annals of the New York Academy of Sciences. August 1956, 65 (3): 91–102. Bibcode:1956NYASA..65...91M. PMID 13363203. S2CID 40134313. doi:10.1111/j.1749-6632.1956.tb36627.x.
- ^ Fux, C.A.; Costerton, J.W.; Stewart, P.S.; Stoodley, P. Survival strategies of infectious biofilms. Trends in Microbiology. January 2005, 13 (1): 34–40. PMID 15639630. doi:10.1016/j.tim.2004.11.010.
- ^ Lewis, Kim. Persister cells, dormancy and infectious disease. Nature Reviews Microbiology. 4 December 2006, 5 (1): 48–56. PMID 17143318. S2CID 6670040. doi:10.1038/nrmicro1557.
- ^ Parsek, Matthew R.; Singh, Pradeep K. Bacterial Biofilms: An Emerging Link to Disease Pathogenesis. Annual Review of Microbiology. October 2003, 57 (1): 677–701. PMID 14527295. doi:10.1146/annurev.micro.57.030502.090720.
- ^ Stewart, PS; Franklin, MJ. Physiological heterogeneity in biofilms.. Nature Reviews. Microbiology. March 2008, 6 (3): 199–210. PMID 18264116. S2CID 5477887. doi:10.1038/nrmicro1838.
- ^ Borriello, G; Richards, L; Ehrlich, GD; Stewart, PS. Arginine or nitrate enhances antibiotic susceptibility of Pseudomonas aeruginosa in biofilms.. Antimicrobial Agents and Chemotherapy. January 2006, 50 (1): 382–4. PMC 1346784 . PMID 16377718. doi:10.1128/AAC.50.1.382-384.2006 .
