SIRT1

SIRT1
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	4I5I、4IF6、4IG9、4KXQ、4ZZH、4ZZI、4ZZJ、5BTR
識別號
别名	SIRT1；, SIR2L1, SIR2, hSIR2, SIR2alpha, Sirtuin 1
外部ID	OMIM：604479 MGI：2135607 HomoloGene：56556 GeneCards：SIRT1
為以下藥物的標靶
	SRT1720
基因位置（人类）
染色体	10號染色體
终止	67,918,390 bp
基因位置（小鼠）
染色体	小鼠10号染色体
终止	63,217,483 bp
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• transcription corepressor activity; • protein domain specific binding; • core promoter sequence-specific DNA binding; • protein C-terminus binding; • keratin filament binding; • 转录因子结合; • 金屬離子結合; • HLH domain binding; • 酶结合; • protein deacetylase activity; • histone binding; • 血浆蛋白结合; • NAD-dependent histone deacetylase activity; • NAD-dependent protein deacetylase activity; • histone deacetylase activity; • p53 binding; • mitogen-activated protein kinase binding; • deacetylase activity; • bHLH transcription factor binding; • NAD+ binding; • 相同蛋白质结合; • NAD+ ADP-ribosyltransferase activity; • 水解酶活性; • NAD-dependent histone deacetylase activity (H3-K9 specific); • DNA-binding transcription activator activity, RNA polymerase II-specific;
細胞組分	• 細胞質; • nuclear envelope; • rDNA heterochromatin; • chromatin silencing complex; • 線粒體; • 细胞核; • ESC/E(Z) complex; • 核仁; • 染色质; • 核质; • PML body; • 內膜; • 细胞质基质;
生物學過程	• cellular triglyceride homeostasis; • positive regulation of MHC class II biosynthetic process; • DNA synthesis involved in DNA repair; • positive regulation of protein phosphorylation; • positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; • rhythmic process; • single strand break repair; • muscle organ development; • histone H3-K9 deacetylation; • negative regulation of cellular response to testosterone stimulus; • regulation of peroxisome proliferator activated receptor signaling pathway; • cellular response to DNA damage stimulus; • regulation of bile acid biosynthetic process; • 脫氧核糖核酸複製; • negative regulation of TOR signaling; • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; • regulation of glucose metabolic process; • rDNA heterochromatin assembly; • negative regulation of DNA damage response, signal transduction by p53 class mediator; • DNA methylation-dependent heterochromatin assembly; • 昼夜节律; • positive regulation of cellular senescence; • 精子发生; • intrinsic apoptotic signaling pathway in response to DNA damage; • cellular response to ionizing radiation; • negative regulation of helicase activity; • cholesterol homeostasis; • response to leptin; • cellular response to hypoxia; • triglyceride mobilization; • negative regulation of prostaglandin biosynthetic process; • proteasome-mediated ubiquitin-dependent protein catabolic process; • 细胞凋亡; • peptidyl-lysine deacetylation; • negative regulation of fat cell differentiation; • negative regulation of peptidyl-lysine acetylation; • regulation of transcription, DNA-templated; • positive regulation of adaptive immune response; • stress-induced premature senescence; • negative regulation of androgen receptor signaling pathway; • negative regulation of transforming growth factor beta receptor signaling pathway; • response to oxidative stress; • negative regulation of DNA-binding transcription factor activity; • negative regulation of gene expression; • transcription, DNA-templated; • negative regulation of cAMP-dependent protein kinase activity; • pyrimidine dimer repair by nucleotide-excision repair; • response to insulin; • histone H3-K9 modification; • positive regulation of macroautophagy; • positive regulation of cholesterol efflux; • protein ubiquitination; • negative regulation of cell growth; • positive regulation of macrophage apoptotic process; • rRNA processing; • regulation of brown fat cell differentiation; • negative regulation of phosphorylation; • viral process; • DNA修復; • negative regulation of neuron death; • positive regulation of histone H3-K9 methylation; • negative regulation of histone H3-K14 acetylation; • negative regulation of protein kinase B signaling; • 细胞分化; • ovulation from ovarian follicle; • regulation of protein serine/threonine kinase activity; • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; • protein ADP-ribosylation; • leptin-mediated signaling pathway; • negative regulation of apoptotic process; • negative regulation of transcription by RNA polymerase II; • chromatin organization; • negative regulation of I-kappaB kinase/NF-kappaB signaling; • circadian regulation of gene expression; • protein deacetylation; • fatty acid homeostasis; • protein destabilization; • regulation of mitotic cell cycle; • positive regulation of cAMP-dependent protein kinase activity; • white fat cell differentiation; • positive regulation of insulin receptor signaling pathway; • negative regulation of transcription, DNA-templated; • negative regulation of NF-kappaB transcription factor activity; • peptidyl-lysine acetylation; • response to hydrogen peroxide; • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; • negative regulation of histone H4-K16 acetylation; • positive regulation of endothelial cell proliferation; • regulation of smooth muscle cell apoptotic process; • behavioral response to starvation; • cellular glucose homeostasis; • cellular response to starvation; • cellular response to tumor necrosis factor; • positive regulation of DNA repair; • multicellular organism development; • regulation of cell population proliferation; • positive regulation of cell population proliferation; • regulation of endodeoxyribonuclease activity; • regulation of cellular response to heat; • positive regulation of phosphatidylinositol 3-kinase signaling; • negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; • UV-damage excision repair; • histone deacetylation; • positive regulation of transcription by RNA polymerase II; • 血管新生; • macrophage cytokine production; • regulation of lipid storage; • positive regulation of adipose tissue development; • macrophage differentiation; • transcription by RNA polymerase II; • positive regulation of smooth muscle cell differentiation; • negative regulation of histone H3-K9 trimethylation; • positive regulation of apoptotic process; • cellular response to hydrogen peroxide; • histone H3 deacetylation; • negative regulation of protein acetylation; • regulation of apoptotic process; • cellular response to leukemia inhibitory factor; • positive regulation of angiogenesis; • transforming growth factor beta receptor signaling pathway; • positive regulation of blood vessel endothelial cell migration; • negative regulation of cellular senescence;
	Sources:Amigo / QuickGO
直系同源
	23411
	93759
	ENSG00000096717
	ENSMUSG00000020063
	Q96EB6
	Q923E4
	NM_001142498; NM_001314049; NM_012238
	NM_001159589; NM_001159590; NM_019812
	NP_001135970; NP_001300978; NP_036370
	NP_001153061; NP_062786
	維基數據
檢視/編輯人類	檢視/編輯小鼠

SIRT1（英語：Sirtuin 1），也被称为 NAD-依赖性去乙酰化酶Sirtuin-1（英語：NAD-dependent deacetylase sirtuin-1），是人类基因组中由SIRT1基因编码的蛋白。人的SIRT1基因位于10号染色体上。SIRT1的功能是去除蛋白质上的乙酰基团（去乙酰化）。SIRT1的去乙酰化功能在一些生物学过程中有发挥一定的作用^[6]^[7]^[8]。

参考文献[编辑]

^ 對SIRT1起作用的藥物；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000096717 - Ensembl, May 2017
^ ^3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000020063 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Frye, R. A. Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. Biochemical and Biophysical Research Communications. 1999-06-24, 260 (1): 273–279 [2021-11-10]. ISSN 0006-291X. PMID 10381378. doi:10.1006/bbrc.1999.0897. （原始内容存档于2021-11-10）.
^ SIRT1 sirtuin 1 [Homo sapiens (human)] - Gene - NCBI. www.ncbi.nlm.nih.gov. [2021-11-10]. （原始内容存档于2021-11-10）.
^ Template:UCSC genome browser

外部链接[编辑]

Corante weblog by Derek Lowe about sir2 and SIRT1 research.

这是一篇與生物化學相關的小作品。你可以通过编辑或修订扩充其内容。

[1] 對SIRT1起作用的藥物；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000096717 - Ensembl, May 2017

[refGRCm38Ensembl-3] 3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000020063 - Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10381378-6] Frye, R. A. Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. Biochemical and Biophysical Research Communications. 1999-06-24, 260 (1): 273–279 [2021-11-10]. ISSN 0006-291X. PMID 10381378. doi:10.1006/bbrc.1999.0897. （原始内容存档于2021-11-10）.

[entrez-7] SIRT1 sirtuin 1 [Homo sapiens (human)] - Gene - NCBI. www.ncbi.nlm.nih.gov. [2021-11-10]. （原始内容存档于2021-11-10）.

[UCSC_SIRT1-8] Template:UCSC genome browser

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