ERG3

Sterol C-5 desaturase
標識
生物	Saccharomyces cerevisiae
符號	ERG3
可選符號	SC5D, SYR1
Entrez	850745
RefSeq （mRNA）	NM_001181943
其他數據
EC number	1.14.19.20
染色體	XII: 0.25 - 0.25 Mb

ERG3 或甾醇-C5-去飽和酶（英語：Sterol C5-desaturase）是真菌釀酒酵母（Saccharomyces cerevisiae）的涉及麥角固醇生物合成的一種酶，與人類基因組中的CS5D同源^[1]，可定位於內質網或囊泡中^[2]^[3]，催化表甾醇的C5(6)脫氫形成雙鍵變為5-脫氫表甾醇，5-脫氫表甾醇之後經歷ERG5、ERG4等多個酶的轉化最終變為麥角固醇^[4]^[5]。

參考文獻[編輯]

^ Hemmi K, Julmanop C, Hirata D, Tsuchiya E, Takemoto JY, Miyakawa T. The physiological roles of membrane ergosterol as revealed by the phenotypes of syr1/erg3 null mutant of Saccharomyces cerevisiae. Bioscience, Biotechnology, and Biochemistry. March 1995, 59 (3): 482–6. PMID 7766188. doi:10.1271/BBB.59.482.
^ Natter K, Leitner P, Faschinger A, Wolinski H, McCraith S, Fields S, Kohlwein SD. The spatial organization of lipid synthesis in the yeast Saccharomyces cerevisiae derived from large scale green fluorescent protein tagging and high resolution microscopy. Molecular & Cellular Proteomics. May 2005, 4 (5): 662–72. PMID 15716577. doi:10.1074/mcp.M400123-MCP200 .
^ Poklepovich TJ, Rinaldi MA, Tomazic ML, Favale NO, Turkewitz AP, Nudel CB, Nusblat AD. The cytochrome b5 dependent C-5(6) sterol desaturase DES5A from the endoplasmic reticulum of Tetrahymena thermophila complements ergosterol biosynthesis mutants in Saccharomyces cerevisiae. Steroids. November 2012, 77 (13): 1313–20. PMC 3501532 . PMID 22982564. doi:10.1016/j.steroids.2012.08.015.
^ Brumfield KM, Moroney JV, Moore TS, Simms TA, Donze D. Functional characterization of the Chlamydomonas reinhardtii ERG3 ortholog, a gene involved in the biosynthesis of ergosterol. PLOS ONE. January 2010, 5 (1): e8659. Bibcode:2010PLoSO...5.8659B. PMC 2799552 . PMID 20084111. doi:10.1371/journal.pone.0008659.
^ Miyazaki T, Miyazaki Y, Izumikawa K, Kakeya H, Miyakoshi S, Bennett JE, Kohno S. Fluconazole treatment is effective against a Candida albicans erg3/erg3 mutant in vivo despite in vitro resistance. Antimicrobial Agents and Chemotherapy. February 2006, 50 (2): 580–6. PMC 1366932 . PMID 16436713. doi:10.1128/AAC.50.2.580-586.2006.
^ Choe S, Noguchi T, Fujioka S, Takatsuto S, Tissier CP, Gregory BD, et al. The Arabidopsis dwf7/ste1 mutant is defective in the delta7 sterol C-5 desaturation step leading to brassinosteroid biosynthesis. The Plant Cell. February 1999, 11 (2): 207–21. PMC 144158 . PMID 9927639. doi:10.1105/tpc.11.2.207.

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[1] Hemmi K, Julmanop C, Hirata D, Tsuchiya E, Takemoto JY, Miyakawa T. The physiological roles of membrane ergosterol as revealed by the phenotypes of syr1/erg3 null mutant of Saccharomyces cerevisiae. Bioscience, Biotechnology, and Biochemistry. March 1995, 59 (3): 482–6. PMID 7766188. doi:10.1271/BBB.59.482.

[2] Natter K, Leitner P, Faschinger A, Wolinski H, McCraith S, Fields S, Kohlwein SD. The spatial organization of lipid synthesis in the yeast Saccharomyces cerevisiae derived from large scale green fluorescent protein tagging and high resolution microscopy. Molecular & Cellular Proteomics. May 2005, 4 (5): 662–72. PMID 15716577. doi:10.1074/mcp.M400123-MCP200 .

[3] Poklepovich TJ, Rinaldi MA, Tomazic ML, Favale NO, Turkewitz AP, Nudel CB, Nusblat AD. The cytochrome b5 dependent C-5(6) sterol desaturase DES5A from the endoplasmic reticulum of Tetrahymena thermophila complements ergosterol biosynthesis mutants in Saccharomyces cerevisiae. Steroids. November 2012, 77 (13): 1313–20. PMC 3501532 . PMID 22982564. doi:10.1016/j.steroids.2012.08.015.

[4] Brumfield KM, Moroney JV, Moore TS, Simms TA, Donze D. Functional characterization of the Chlamydomonas reinhardtii ERG3 ortholog, a gene involved in the biosynthesis of ergosterol. PLOS ONE. January 2010, 5 (1): e8659. Bibcode:2010PLoSO...5.8659B. PMC 2799552 . PMID 20084111. doi:10.1371/journal.pone.0008659.

[5] Miyazaki T, Miyazaki Y, Izumikawa K, Kakeya H, Miyakoshi S, Bennett JE, Kohno S. Fluconazole treatment is effective against a Candida albicans erg3/erg3 mutant in vivo despite in vitro resistance. Antimicrobial Agents and Chemotherapy. February 2006, 50 (2): 580–6. PMC 1366932 . PMID 16436713. doi:10.1128/AAC.50.2.580-586.2006.

[6] Choe S, Noguchi T, Fujioka S, Takatsuto S, Tissier CP, Gregory BD, et al. The Arabidopsis dwf7/ste1 mutant is defective in the delta7 sterol C-5 desaturation step leading to brassinosteroid biosynthesis. The Plant Cell. February 1999, 11 (2): 207–21. PMC 144158 . PMID 9927639. doi:10.1105/tpc.11.2.207.

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