ERG5

Sterol 22-desaturase
標識
生物	Saccharomyces cerevisiae S288c
符號	ERG5
可選符號	CYP61A1
Entrez	855029
RefSeq （mRNA）	NM_001182511.1
RefSeq （蛋白質）	NP_013728.1
UniProt	P54781
其他數據
EC number	1.14.19.41
染色體	XIII: 0.3 - 0.3 Mb

ERG5 或固醇-22-去飽和酶（英語：Sterol 22-desaturase）是真菌釀酒酵母（Saccharomyces cerevisiae）基因組中的一個涉及麥角固醇生物合成的細胞色素P450 酶，其CYP編號為CYP61A1^[1]，是釀酒酵母三種細胞色素P450基因之一，另外兩種是CYP51F1和CYP56A1^[2]。ERG5可催化類固醇C17側鏈上C22-C23位置脫氫形成雙鍵，如麥角固醇生物合成中的5-脫氫表甾醇（也稱為「麥角三烯醇」）轉化為麥角四烯醇，之後麥角四烯醇的C24雙鍵會被酶ERG4 加氫還原為麥角固醇^[3]。

參考文獻[編輯]

^ Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, Dephoure N, et al. Global analysis of protein expression in yeast. Nature. October 2003, 425 (6959): 737–41. Bibcode:2003Natur.425..737G. PMID 14562106. doi:10.1038/nature02046.
^ Nelson DR. Cytochrome P450 diversity in the tree of life. Biochimica et Biophysica Acta. Proteins and Proteomics. January 2018, 1866 (1): 141–154. PMC 5681887 . PMID 28502748. doi:10.1016/j.bbapap.2017.05.003.
^ Kelly SL, Lamb DC, Baldwin BC, Corran AJ, Kelly DE. Characterization of Saccharomyces cerevisiae CYP61, sterol delta22-desaturase, and inhibition by azole antifungal agents. The Journal of Biological Chemistry. April 1997, 272 (15): 9986–8. PMID 9092539. doi:10.1074/JBC.272.15.9986.

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[1] Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, Dephoure N, et al. Global analysis of protein expression in yeast. Nature. October 2003, 425 (6959): 737–41. Bibcode:2003Natur.425..737G. PMID 14562106. doi:10.1038/nature02046.

[2] Nelson DR. Cytochrome P450 diversity in the tree of life. Biochimica et Biophysica Acta. Proteins and Proteomics. January 2018, 1866 (1): 141–154. PMC 5681887 . PMID 28502748. doi:10.1016/j.bbapap.2017.05.003.

[3] Kelly SL, Lamb DC, Baldwin BC, Corran AJ, Kelly DE. Characterization of Saccharomyces cerevisiae CYP61, sterol delta22-desaturase, and inhibition by azole antifungal agents. The Journal of Biological Chemistry. April 1997, 272 (15): 9986–8. PMID 9092539. doi:10.1074/JBC.272.15.9986.

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