賽克利嗪

**賽克利嗪**
臨床資料
商品名（英語：Drug nomenclature）	Marezine, Valoid, Nausicalm, others
AHFS/Drugs.com	消費者藥物信息
懷孕分級	澳: A ; ;
給藥途徑	口服、IM、IV
ATC碼	R06AE03 (WHO) ;
法律規範狀態
法律規範	澳：限藥劑師（S3）; 英：藥房藥品; 美：OTC; 荷蘭：OTC;
藥物動力學數據
藥物代謝	N-脫甲基成二苯甲基哌嗪（英語：norcyclizine）
生物半衰期	20小時
識別資訊
	IUPAC命名法 1-benzhydryl-4-methyl-piperazine; ;
CAS號	82-92-8
PubChem CID	6726;
IUPHAR/BPS	7151;
DrugBank	DB01176 ;
ChemSpider	6470 ;
UNII	QRW9FCR9P2;
KEGG	D03621 ;
ChEBI	CHEBI:3994 ;
ChEMBL	ChEMBL648 ;
CompTox Dashboard（英語：CompTox Chemicals Dashboard） (EPA)	DTXSID4022864 ;
ECHA InfoCard	100.001.314
化學資訊
化學式	C18H22N2
摩爾質量	266.39 g·mol−1
3D模型（JSmol（英語：JSmol））	交互式圖像;
	SMILES CN(CC1)CCN1C(C2=CC=CC=C2)C3=CC=CC=C3;
	InChI InChI=1S/C18H22N2/c1-19-12-14-20(15-13-19)18(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18H,12-15H2,1H3 ; Key:UVKZSORBKUEBAZ-UHFFFAOYSA-N ;

賽克利嗪（英語：Cyclizine）是用於治療和預防暈車造成的噁心、嘔吐、頭暈的藥物，^[2]也可用於治療全身麻醉或使用阿片類後導致的噁心。^[2]^[3]它通過口服、直腸（英語：Rectal administration）或靜脈給藥。^[3]^[4]

賽克利嗪常見的副作用包括嗜睡、口乾、便秘、視力問題，更嚴重的副作用則包括低血壓和尿瀦留。^[5]一般不推薦兒童和青光眼患者使用賽克利嗪。^[2]^[6]賽克利嗪看起來對孕婦安全，但這尚未得到充分研究。^[7]它屬於抗膽鹼劑和抗組織胺藥。^[3]^[6]

賽克利嗪於1947年被發現。^[8]它是世界衛生組織基本藥物，^[9]在美國是非處方藥。^[6]

參考資料[編輯]

^ DrugBank: Cyclizine. Pharmacology: metabolism. DrugBank Database. [5 January 2016]. （原始內容存檔於30 January 2016）.
^ ^2.0 ^2.1 ^2.2 Cyclizine 50mg Tablets - Summary of Product Characteristics (SPC) - (eMC). www.medicines.org.uk. 27 March 2015 [13 December 2016]. （原始內容存檔於20 December 2016）.
^ ^3.0 ^3.1 ^3.2 Feldman M, Friedman LS, Brandt LJ. Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. Elsevier Health Sciences. 2015: 218. ISBN 9781455749898. （原始內容存檔於2016-12-20）.
^ World Health Organization. World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. 2019. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^ Cyclizine Side Effects in Detail - Drugs.com. www.drugs.com. [13 December 2016]. （原始內容存檔於21 December 2016）.
^ ^6.0 ^6.1 ^6.2 Cyclizine: Indications, Side Effects, Warnings - Drugs.com. www.drugs.com. [13 December 2016]. （原始內容存檔於21 December 2016）.
^ Cyclizine Use During Pregnancy | Drugs.com. www.drugs.com. [13 December 2016]. （原始內容存檔於21 December 2016）.
^ Williams P. The story of the Wellcome Trust : unlocking Sir Henry's legacy to medical research. Hindringham: JJG. 2010: 14. ISBN 9781899163922. （原始內容存檔於2016-12-20）.
^ World Health Organization. World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. 2021. hdl:10665/345533 . WHO/MHP/HPS/EML/2021.02.

外部連結[編輯]

Cyclizine. Drug Information Portal. U.S. National Library of Medicine. [2023-10-22]. （原始內容存檔於2022-10-27）.

[1] DrugBank: Cyclizine. Pharmacology: metabolism. DrugBank Database. [5 January 2016]. （原始內容存檔於30 January 2016）.

[ERC2015-2] 2.0 ^2.1 ^2.2 Cyclizine 50mg Tablets - Summary of Product Characteristics (SPC) - (eMC). www.medicines.org.uk. 27 March 2015 [13 December 2016]. （原始內容存檔於20 December 2016）.

[Fe2015-3] 3.0 ^3.1 ^3.2 Feldman M, Friedman LS, Brandt LJ. Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. Elsevier Health Sciences. 2015: 218. ISBN 9781455749898. （原始內容存檔於2016-12-20）.

[WHO21st-4] World Health Organization. World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. 2019. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.

[SFX2016-5] Cyclizine Side Effects in Detail - Drugs.com. www.drugs.com. [13 December 2016]. （原始內容存檔於21 December 2016）.

[CDI2016-6] 6.0 ^6.1 ^6.2 Cyclizine: Indications, Side Effects, Warnings - Drugs.com. www.drugs.com. [13 December 2016]. （原始內容存檔於21 December 2016）.

[7] Cyclizine Use During Pregnancy | Drugs.com. www.drugs.com. [13 December 2016]. （原始內容存檔於21 December 2016）.

[8] Williams P. The story of the Wellcome Trust : unlocking Sir Henry's legacy to medical research. Hindringham: JJG. 2010: 14. ISBN 9781899163922. （原始內容存檔於2016-12-20）.

[WHO22nd-9] World Health Organization. World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. 2021. hdl:10665/345533 . WHO/MHP/HPS/EML/2021.02.

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