A-704

A-704是人類腎細胞癌（英语：Renal cell carcinoma）細胞系，最初是分離自一名78歲的人類男性腎細胞癌患者^[1]，存在着SETD2基因（英语：SETD2）突變^[2]。

科研用途[编辑]

2016年，有科研人員假設USP21基因的表達可能與腎細胞癌的腫瘤進展有關，其後在A-704細胞中使用小分子干擾核糖核酸誘導了USP21基因的減少，發現顯著抑制了A-704細胞的生長及侵襲能力，並且發現USP21基因的過度表達會促進A-704細胞的致瘤能力^[3]。同年進行的另一項研究則使用小干擾RNA 敲落A-704細胞中的FKBP10，並且評估細胞增殖、細胞週期進程及侵襲能力，繼而評估了FK506結合蛋白在腎細胞癌中的表達和功能。實驗發現FKBP10（英语：FKBP10）的敲落導致細胞週期停在G0/G1期，並且減少A-704細胞的增殖及侵襲能力^[4]。

參考資料[编辑]

^ Giard, DJ; Aaronson, SA; Todaro, GJ; Arnstein, P; Kersey, JH; Dosik, H; Parks, WP. In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors.. Journal of the National Cancer Institute. 1973-11, 51 (5): 1417–23 [2019-12-27]. PMID 4357758. doi:10.1093/jnci/51.5.1417. （原始内容存档于2019-12-27）.
^ Bihr, S; Ohashi, R; Moore, AL; Rüschoff, JH; Beisel, C; Hermanns, T; Mischo, A; Corrò, C; Beyer, J; Beerenwinkel, N; Moch, H; Schraml, P. Expression and Mutation Patterns of PBRM1, BAP1 and SETD2 Mirror Specific Evolutionary Subtypes in Clear Cell Renal Cell Carcinoma.. Neoplasia (New York, N.Y.). 2019-02, 21 (2): 247–256 [2019-12-27]. PMID 30660076. doi:10.1016/j.neo.2018.12.006. （原始内容存档于2019-12-27）.
^ Peng, L; Hu, Y; Chen, D; Jiao, S; Sun, S. Ubiquitin specific peptidase 21 regulates interleukin-8 expression, stem-cell like property of human renal cell carcinoma.. Oncotarget. 2016-07-05, 7 (27): 42007–42016 [2019-12-27]. PMID 27259257. doi:10.18632/oncotarget.9751.
^ Ge, Y; Xu, A; Zhang, M; Xiong, H; Fang, L; Zhang, X; Liu, C; Wu, S. FK506 Binding Protein 10 Is Overexpressed and Promotes Renal Cell Carcinoma.. Urologia internationalis. 2017, 98 (2): 169–176 [2019-12-27]. PMID 27602571. doi:10.1159/000448338. （原始内容存档于2019-12-27）.

外部連結[编辑]

Cellosaurus entry for A-704（页面存档备份，存于互联网档案馆）

[1] Giard, DJ; Aaronson, SA; Todaro, GJ; Arnstein, P; Kersey, JH; Dosik, H; Parks, WP. In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors.. Journal of the National Cancer Institute. 1973-11, 51 (5): 1417–23 [2019-12-27]. PMID 4357758. doi:10.1093/jnci/51.5.1417. （原始内容存档于2019-12-27）.

[2] Bihr, S; Ohashi, R; Moore, AL; Rüschoff, JH; Beisel, C; Hermanns, T; Mischo, A; Corrò, C; Beyer, J; Beerenwinkel, N; Moch, H; Schraml, P. Expression and Mutation Patterns of PBRM1, BAP1 and SETD2 Mirror Specific Evolutionary Subtypes in Clear Cell Renal Cell Carcinoma.. Neoplasia (New York, N.Y.). 2019-02, 21 (2): 247–256 [2019-12-27]. PMID 30660076. doi:10.1016/j.neo.2018.12.006. （原始内容存档于2019-12-27）.

[3] Peng, L; Hu, Y; Chen, D; Jiao, S; Sun, S. Ubiquitin specific peptidase 21 regulates interleukin-8 expression, stem-cell like property of human renal cell carcinoma.. Oncotarget. 2016-07-05, 7 (27): 42007–42016 [2019-12-27]. PMID 27259257. doi:10.18632/oncotarget.9751.

[4] Ge, Y; Xu, A; Zhang, M; Xiong, H; Fang, L; Zhang, X; Liu, C; Wu, S. FK506 Binding Protein 10 Is Overexpressed and Promotes Renal Cell Carcinoma.. Urologia internationalis. 2017, 98 (2): 169–176 [2019-12-27]. PMID 27602571. doi:10.1159/000448338. （原始内容存档于2019-12-27）.

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