A-704

A-704是人类肾细胞癌（英语：Renal cell carcinoma）细胞系，最初是分离自一名78岁的人类男性肾细胞癌患者^[1]，存在着SETD2基因（英语：SETD2）突变^[2]。

科研用途[编辑]

2016年，有科研人员假设USP21基因的表达可能与肾细胞癌的肿瘤进展有关，其后在A-704细胞中使用小分子干扰核糖核酸诱导了USP21基因的减少，发现显著抑制了A-704细胞的生长及侵袭能力，并且发现USP21基因的过度表达会促进A-704细胞的致瘤能力^[3]。同年进行的另一项研究则使用小干扰RNA 敲落A-704细胞中的FKBP10，并且评估细胞增殖、细胞周期进程及侵袭能力，继而评估了FK506结合蛋白在肾细胞癌中的表达和功能。实验发现FKBP10（英语：FKBP10）的敲落导致细胞周期停在G0/G1期，并且减少A-704细胞的增殖及侵袭能力^[4]。

参考资料[编辑]

^ Giard, DJ; Aaronson, SA; Todaro, GJ; Arnstein, P; Kersey, JH; Dosik, H; Parks, WP. In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors.. Journal of the National Cancer Institute. 1973-11, 51 (5): 1417–23 [2019-12-27]. PMID 4357758. doi:10.1093/jnci/51.5.1417. （原始内容存档于2019-12-27）.
^ Bihr, S; Ohashi, R; Moore, AL; Rüschoff, JH; Beisel, C; Hermanns, T; Mischo, A; Corrò, C; Beyer, J; Beerenwinkel, N; Moch, H; Schraml, P. Expression and Mutation Patterns of PBRM1, BAP1 and SETD2 Mirror Specific Evolutionary Subtypes in Clear Cell Renal Cell Carcinoma.. Neoplasia (New York, N.Y.). 2019-02, 21 (2): 247–256 [2019-12-27]. PMID 30660076. doi:10.1016/j.neo.2018.12.006. （原始内容存档于2019-12-27）.
^ Peng, L; Hu, Y; Chen, D; Jiao, S; Sun, S. Ubiquitin specific peptidase 21 regulates interleukin-8 expression, stem-cell like property of human renal cell carcinoma.. Oncotarget. 2016-07-05, 7 (27): 42007–42016 [2019-12-27]. PMID 27259257. doi:10.18632/oncotarget.9751.
^ Ge, Y; Xu, A; Zhang, M; Xiong, H; Fang, L; Zhang, X; Liu, C; Wu, S. FK506 Binding Protein 10 Is Overexpressed and Promotes Renal Cell Carcinoma.. Urologia internationalis. 2017, 98 (2): 169–176 [2019-12-27]. PMID 27602571. doi:10.1159/000448338. （原始内容存档于2019-12-27）.

外部链接[编辑]

Cellosaurus entry for A-704（页面存档备份，存于互联网档案馆）

[1] Giard, DJ; Aaronson, SA; Todaro, GJ; Arnstein, P; Kersey, JH; Dosik, H; Parks, WP. In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors.. Journal of the National Cancer Institute. 1973-11, 51 (5): 1417–23 [2019-12-27]. PMID 4357758. doi:10.1093/jnci/51.5.1417. （原始内容存档于2019-12-27）.

[2] Bihr, S; Ohashi, R; Moore, AL; Rüschoff, JH; Beisel, C; Hermanns, T; Mischo, A; Corrò, C; Beyer, J; Beerenwinkel, N; Moch, H; Schraml, P. Expression and Mutation Patterns of PBRM1, BAP1 and SETD2 Mirror Specific Evolutionary Subtypes in Clear Cell Renal Cell Carcinoma.. Neoplasia (New York, N.Y.). 2019-02, 21 (2): 247–256 [2019-12-27]. PMID 30660076. doi:10.1016/j.neo.2018.12.006. （原始内容存档于2019-12-27）.

[3] Peng, L; Hu, Y; Chen, D; Jiao, S; Sun, S. Ubiquitin specific peptidase 21 regulates interleukin-8 expression, stem-cell like property of human renal cell carcinoma.. Oncotarget. 2016-07-05, 7 (27): 42007–42016 [2019-12-27]. PMID 27259257. doi:10.18632/oncotarget.9751.

[4] Ge, Y; Xu, A; Zhang, M; Xiong, H; Fang, L; Zhang, X; Liu, C; Wu, S. FK506 Binding Protein 10 Is Overexpressed and Promotes Renal Cell Carcinoma.. Urologia internationalis. 2017, 98 (2): 169–176 [2019-12-27]. PMID 27602571. doi:10.1159/000448338. （原始内容存档于2019-12-27）.

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