胱天蛋白酶4

CASP4
識別號
别名	CASP4；, ICE(rel)II, ICEREL-II, ICH-2, Mih1/TX, TX, Mih1, caspase 4
外部ID	OMIM：602664 MGI：107700 HomoloGene：136493 GeneCards：CASP4
為以下藥物的標靶
	emricasan
基因位置（人类）
染色体	11號染色體
终止	104,969,366 bp
基因位置（小鼠）
染色体	小鼠9号染色体
终止	5,336,783 bp
基因本體
分子功能	• 半胱氨酸型肽酶活性; • 肽酶活性; • 水解酶活性; • cysteine-type endopeptidase activity involved in execution phase of apoptosis; • cysteine-type endopeptidase activity involved in apoptotic process; • cysteine-type endopeptidase activity; • CARD domain binding; • cysteine-type endopeptidase activity involved in apoptotic signaling pathway; • 血浆蛋白结合;
細胞組分	• NLRP3 inflammasome complex; • 細胞質; • endoplasmic reticulum membrane; • 膜; • 細胞外區域; • AIM2 inflammasome complex; • IPAF inflammasome complex; • 内质网; • 線粒體; • 炎性小體; • 细胞质基质; • 细胞膜; • 大分子复合体;
生物學過程	• regulation of apoptotic process; • 细胞程序性死亡; • immune system process; • 蛋白酶解; • intrinsic apoptotic signaling pathway; • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; • regulation of inflammatory response; • 先天免疫系統; • inflammatory response; • cellular response to amyloid-beta; • 细胞凋亡; • execution phase of apoptosis; • positive regulation of tumor necrosis factor-mediated signaling pathway; • activation of cysteine-type endopeptidase activity involved in apoptotic process;
	Sources:Amigo / QuickGO
直系同源
	837
	12363
	ENSG00000196954
	ENSMUSG00000033538
	P49662
	P70343
	NM_001225; NM_033306; NM_033307
	NM_007609
	NP_001216; NP_150649
NP_031635; NP_001366247; NP_001366248; NP_001366249; NP_001366250;
	NP_001366251; NP_001366252
	維基數據
檢視/編輯人類	檢視/編輯小鼠

胱天蛋白酶4（英语：Caspase 4）是一种在人类中由CASP4基因编码的酶。该酶属于胱天蛋白酶（Caspase）家族的成员。该酶是一种在天冬氨酸残基（LEVD-）处以蛋白水解方式裂解其他蛋白质的酶，其余的功能尚未完全了解，但据信它是一种炎症性胱天蛋白酶，与胱天蛋白酶1、5（以及鼠同源物胱天蛋白酶11）一起在免疫系统中发挥作用。^[6]

抗炎药吲哚布洛芬是胱天蛋白酶4酶活性的抑制剂。^[7]

参见[编辑]

蛋白酶解图谱（英语：The Proteolysis Map）
胱天蛋白酶

参考文献[编辑]

^ 對胱天蛋白酶4起作用的藥物；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000196954 - Ensembl, May 2017
^ ^3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000033538 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Martinon F, Tschopp J. Inflammatory caspases and inflammasomes: master switches of inflammation. Cell Death Differ. 2007, 14 (1): 10–22. PMID 16977329. doi:10.1038/sj.cdd.4402038 .
^ Smith C, Soti S, Jones Torey A, Nakagawa A, Xue D, and Yin H. NSAIDs are Caspase Inhibitors. Cell Chem Biol. 2017, 24 (3): 281–292. PMC 5357154 . PMID 28238723. doi:10.1016/j.chembiol.2017.02.003 .

外部链接[编辑]

肽酶及其抑制剂的MEROPS在线数据库：C14.007^{[失效連結]}

[1] 對胱天蛋白酶4起作用的藥物；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000196954 - Ensembl, May 2017

[refGRCm38Ensembl-3] 3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000033538 - Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[6] Martinon F, Tschopp J. Inflammatory caspases and inflammasomes: master switches of inflammation. Cell Death Differ. 2007, 14 (1): 10–22. PMID 16977329. doi:10.1038/sj.cdd.4402038 .

[7] Smith C, Soti S, Jones Torey A, Nakagawa A, Xue D, and Yin H. NSAIDs are Caspase Inhibitors. Cell Chem Biol. 2017, 24 (3): 281–292. PMC 5357154 . PMID 28238723. doi:10.1016/j.chembiol.2017.02.003 .

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